Natural Viagra
https://eddrugs2017.com/natural-alternatives-viagra/ Being allocated from endothelial cells of NO diffuses in a subject gladkomyshechny tissue where enzyme гуанилатциклаза therefore the quantity sharply increases in cells cyclic a guanosine of mononatrii phosphas (CGMP) is activated that, in turn conducts to depression of intracellular concentration of ions of a calcium and a relaxation. The destruction of the CGMP limiting vazorelaksiruyushchy effect of NO, is carried out by enzyme фосфодиэстераза (FDE). Now 11 types of this enzyme are known, thus in CGMP destruction in the gladkomyshechnykh cells of vessels the main role is played by FDE 1,3 and 5 of types [5]. Thus, oppression of FDE leads to intensifying of effects of oxide of nitrogen.
The erection of a penis is the hemodynamic phenomenon which first stage is the relaxation the gladkomyshechnykh of cells of cavernous arteries and the trabeculas, bringing to filling with a blood of cavernous ph. The relaxation of a gladkomyshechny tissue of the last, as well as in other vascular systems, is provided with action of NO which is allocating from an endothelium and not cholinergic not adrenergic nervous terminations [6]. Discovery of Natural Viagra, a selective inhibitor (FDE-5) FDE 5, became the reason of the numerous basic researches which have shown what exactly this type of enzyme dominates in a cavernous tissue that provides selectivity of influence of a preparation [7]. It is necessary to notice that these researches allowed to find out also mechanisms of action and others, already long time of preparations applied in clinical practice, in particular, a papaverine and E1 [8] prostaglandin, and considerably to dilate knowledge of the mechanism of an erection and its disturbances leading to ED.